Here is the synthesis of Isoniazid, an essential component of all antitubercular regimens. It is primarly tuberculocidal.

IUPAC Name Pyridine-4-carbohydrazide

Structure

isoniazid structure
Synthesis

isoniazid synthesis
Uses

  • Very first line drug for Tuberculosis.

Adverse Effects

  • Peripheral Neuritis, parathesis, numbness, mental disturbances are dose-dependent toxic effects

  • Hepatitis, a major adverse effect, is rare in children but more common in older people and in alcoholics

  • Others - lethargy, rashes, mild anaemia and arthralgia (joint pain)