  Here is the synthesis of Isoniazid, an essential component of all antitubercular regimens. It is primarly tuberculocidal.
IUPAC Name Pyridine-4-carbohydrazide
Structure
Synthesis
Uses
  • Very first line drug for Tuberculosis.
Adverse Effects
  • Peripheral Neuritis, parathesis, numbness, mental disturbances are dose-dependent toxic effects
  • Hepatitis, a major adverse effect, is rare in children but more common in older people and in alcoholics
  • Others - lethargy, rashes, mild anaemia and arthralgia (joint pain)
IUPAC Name Pyridine-4-carbohydrazide
Structure
Synthesis
Uses
  • Very first line drug for Tuberculosis.
Adverse Effects
  • Peripheral Neuritis, parathesis, numbness, mental disturbances are dose-dependent toxic effects
  • Hepatitis, a major adverse effect, is rare in children but more common in older people and in alcoholics
  • Others - lethargy, rashes, mild anaemia and arthralgia (joint pain)
