IUPAC - 1-(isopropyl amino)-3-(1-napthyloxy)-2-propanol
Synthesis
Step 1 : Alpha-napthol is reacted with
epichlorohydrin, (-HCl
hydrochloric acid) is eliminated.
Step 2 : To the intermediate compound,
Isopropylamine is added, results
in Propranolol.
Mechanism of Action
Propranolol bind with beta
1 and 2 receptor. It has equal affinity for both the receptors.
On binding with beta-1 : Decreased renin
release
On binding with beta-2 : Decreased heart
rate, Vasoconstriction, Bronchoconstriction, Decreased blood pressure
Uses
Hypertension
Angina Pectoris
Cardiac arrhythmias
Migraine
Anxiety
Adverse Effects
Bradycardia, Worsens COPD, Tiredness, Cold hands and feet
